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(獅子、狐貍等野生動物的)獸穴，獸窩
A den is the home of certain types of wild animals such as lions or foxes.
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(家里用來學習、工作或從事業余愛好的)書房，私室
Your den is a quiet room in your house where you can go to study, work, or carry on a hobby without being disturbed.
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(通常指為了從事非法活動的)秘密聚集處，窩點，巢穴
A den is a secret place where people meet, usually for a dishonest purpose.
例句
I could provide you with the addresses of at least three illegal drinking dens.
我可以為你提供至少 3 處非法飲酒窩點的地址。
...the crack dens of urban America.
美國城市中的可卡因毒窟
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(某一不良行為或非法活動的猖獗)場所，淵藪
If you describe a place as a den of a particular type of bad or illegal behaviour, you mean that a lot of that type of behaviour goes on there.
例句
...the one-bedroomed flat that was to become his den of savage debauchery.
即將成為他野蠻放蕩之所的一居室公寓
...a den of greed.
貪欲橫行之地